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Growth factors in idiopathic pulmonary fibrosis: relative roles

Allen, JT and Spiteri, MA 2002, 'Growth factors in idiopathic pulmonary fibrosis: relative roles' , Respiratory Research, 3 (1) , pp. 13-22.

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    Abstract

    Treatment of idiopathic pulmonary fibrosis patients has evolved very slowly; the fundamental approach of corticosteroids alone or in combination with other immunosuppressive agents has had little impact on long-term survival. The continued use of corticosteroids is justified because of the lack of a more effective alternative. Current research indicates that the mechanisms driving idiopathic pulmonary fibrosis reflect abnormal, dysregulated wound healing within the lung, involving increased activity and possibly exaggerated responses by a spectrum of profibrogenic growth factors. An understanding of the roles of these growth factors, and the way in which they modulate events at cellular level, could lead to more targeted therapeutic strategies, improving patients' quality of life and survival.

    Item Type: Article
    Uncontrolled Keywords: Alveolar epithelial cell, apoptosis, growth factor, idiopathic pulmonary fibrosis, myofibroblast
    Themes: Subjects / Themes > R Medicine > R Medicine (General)
    Health and Wellbeing
    Schools: Colleges and Schools > College of Science & Technology
    Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
    Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
    Journal or Publication Title: Respiratory Research
    Publisher: BioMed Central
    Refereed: Yes
    ISSN: 14659921
    Related URLs:
    Depositing User: H Kenna
    Date Deposited: 07 Aug 2007 09:32
    Last Modified: 20 Aug 2013 16:45
    URI: http://usir.salford.ac.uk/id/eprint/123

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