Growth factors in idiopathic pulmonary fibrosis: relative roles
Allen, JT and Spiteri, MA 2002, 'Growth factors in idiopathic pulmonary fibrosis: relative roles' , Respiratory Research, 3 (1) , pp. 13-22.
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Treatment of idiopathic pulmonary fibrosis patients has evolved very slowly; the fundamental approach of corticosteroids alone or in combination with other immunosuppressive agents has had little impact on long-term survival. The continued use of corticosteroids is justified because of the lack of a more effective alternative. Current research indicates that the mechanisms driving idiopathic pulmonary fibrosis reflect abnormal, dysregulated wound healing within the lung, involving increased activity and possibly exaggerated responses by a spectrum of profibrogenic growth factors. An understanding of the roles of these growth factors, and the way in which they modulate events at cellular level, could lead to more targeted therapeutic strategies, improving patients' quality of life and survival.
|Uncontrolled Keywords:||Alveolar epithelial cell, apoptosis, growth factor, idiopathic pulmonary fibrosis, myofibroblast|
|Themes:||Subjects / Themes > R Medicine > R Medicine (General)
Health and Wellbeing
|Schools:||Schools > School of Environment and Life Sciences
Schools > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
|Journal or Publication Title:||Respiratory Research|
|Depositing User:||H Kenna|
|Date Deposited:||07 Aug 2007 08:32|
|Last Modified:||01 Dec 2015 00:03|
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