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Protein and cell engineering of components of the human receptor/effector system: applications for therapy and diagnosis

Helm, BA, Sayers, I, Swann, J, Smyth, LJC, Cain, SA, Suter, M, Machado, DC, Spivey, AC and Padlan, EA 1998, 'Protein and cell engineering of components of the human receptor/effector system: applications for therapy and diagnosis' , Technology and Health Care, 6 (2-3) , pp. 195-207.

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Abstract

Adaptive immune responses characterised by the synthesis of antibodies of the immunoglobulin E (IgE) isotype play an important role in type I hypersensitivity disorders and parasitic infestations, diseases which have an significant socio-economic impact world-wide. This paper considers potential applications of recent advances in our understanding of the origin of isotype specific immune responses which emerged as a result of cell and protein engineering studies on components of the human IgE/receptor/effector system. Furthermore, the identification of the receptor binding regions in IgE as a result of the development of a stable assay system has important applications for the design of rational therapeutic interventions in allergy and asthma, the treatment of mast cell tumours, and the establishment of procedures for the selective isolation of cells expressing the high-affinity receptor for IgE for functional studies.

Item Type: Article
Themes: Subjects / Themes > Q Science > QR Microbiology
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Journal or Publication Title: Technology and Health Care
Publisher: IOS Press
Refereed: Yes
ISSN: 0928-7329
Depositing User: Users 29196 not found.
Date Deposited: 23 Dec 2010 14:49
Last Modified: 20 Aug 2013 17:44
URI: http://usir.salford.ac.uk/id/eprint/12673

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