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Fcgamma RIIa polymorphism in systemic lupus erythematosus

Smyth, LJC, Snowden, N, Carthy, D, Papasteriades, C, Hajeer, A and Ollier, WER 1997, 'Fcgamma RIIa polymorphism in systemic lupus erythematosus' , Annals of the Rheumatic Diseases, 56 (12) , pp. 744-746.

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Abstract

OBJECTIVES Polymorphism of the phagocyte IgG receptor FcγRIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupus nephritis. FcγRIIa is biallelic, the alleles R and H each having a gene frequency of about 50%. Nephritis has been associated with an increased frequency of the R allele. The frequency of common FcγRIIa alleles was examined in white subjects from the United Kingdom and Greek subjects with systemic lupus erythematosus (SLE) and healthy controls. METHODS FcγRIIa genotyping was performed using a single step polymerase chain reaction technique, which differentiates the two major alleles, R and H. Two study populations were examined: (a) white subjects from the United Kingdom : 66 controls and 81 with SLE (19 of whom had renal disease) and (b) Greek: 52 controls and 42 with SLE (19 with renal disease). RESULTS No significant relation was observed between FcγRIIa genotype and susceptibility to SLE or SLE nephritis. CONCLUSIONS The FcγRIIa R allele does not seem to be associated with SLE (with or without renal disease) in our United Kingdom white or Greek populations.

Item Type: Article
Themes: Subjects / Themes > Q Science > QR Microbiology
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Journal or Publication Title: Annals of the Rheumatic Diseases
Publisher: BMJ Publishing Group
Refereed: Yes
ISSN: 0003-4967
Depositing User: Users 29196 not found.
Date Deposited: 23 Dec 2010 14:53
Last Modified: 20 Aug 2013 17:44
URI: http://usir.salford.ac.uk/id/eprint/12691

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