Schinzer, D, Bourguet, E and Ducki, S 2004, 'Synthesis of furano-epothilone D' , Chemistry - A European Journal, 10 (13) , pp. 3217-3224.

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Abstract

The total synthesis of furano-epothilone D by a convergent route is reported. The key fragments are available on a large scale to provide sufficient material for biological evaluation. The approach involves a palladium-catalyzed coupling that generates a highly functionalized aldehyde which is connected in a stereoselective aldol reaction to yield the framework of furano-epothilone D. Finally, a macrolactonization provides furano-epothilone D.

Item Type:	Article
Uncontrolled Keywords:	Aldol reactions, antitumor agents, epothilone analogues, macrolides, natural products
Themes:	Subjects / Themes > Q Science > Q Science (General) Subjects outside of the University Themes
Schools:	Colleges and Schools > College of Science & Technology Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Journal or Publication Title:	Chemistry - A European Journal
Publisher:	John Wiley & Sons
Refereed:	Yes
ISSN:	09476539
Depositing User:	H Kenna
Date Deposited:	07 Aug 2007 13:59
Last Modified:	27 Sep 2011 12:25
URI:	http://usir.salford.ac.uk/id/eprint/141

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