Synthesis of furano-epothilone D
Schinzer, D, Bourguet, E and Ducki, S 2004, 'Synthesis of furano-epothilone D' , Chemistry - A European Journal, 10 (13) , pp. 3217-3224.Full text not available from this repository.
The total synthesis of furano-epothilone D by a convergent route is reported. The key fragments are available on a large scale to provide sufficient material for biological evaluation. The approach involves a palladium-catalyzed coupling that generates a highly functionalized aldehyde which is connected in a stereoselective aldol reaction to yield the framework of furano-epothilone D. Finally, a macrolactonization provides furano-epothilone D.
|Uncontrolled Keywords:||Aldol reactions, antitumor agents, epothilone analogues, macrolides, natural products|
|Themes:||Subjects / Themes > Q Science > Q Science (General)|
Subjects outside of the University Themes
|Schools:||Colleges and Schools > College of Science & Technology|
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
|Journal or Publication Title:||Chemistry - A European Journal|
|Publisher:||John Wiley & Sons|
|Depositing User:||H Kenna|
|Date Deposited:||07 Aug 2007 13:59|
|Last Modified:||27 Sep 2011 12:25|
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