Chiang, GCH, Ayscough, A, Bond, AD, Pain, G, Ducki, S and Holmes, AB 2005, 'Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy' , Chemical Communications (14) , pp. 1860-1862.

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Abstract

The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties in the micromolar range.

Item Type:	Article
Themes:	Subjects / Themes > Q Science > Q Science (General) Subjects / Themes > Q Science > QD Chemistry Subjects outside of the University Themes
Schools:	Colleges and Schools > College of Science & Technology Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Journal or Publication Title:	Chemical Communications
Publisher:	Royal Society of Chemistry
Refereed:	Yes
ISSN:	13597345
Depositing User:	H Kenna
Date Deposited:	07 Aug 2007 14:02
Last Modified:	27 Sep 2011 12:24
URI:	http://usir.salford.ac.uk/id/eprint/142

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