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Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy

Chiang, GCH, Ayscough, A, Bond, AD, Pain, G, Ducki, S and Holmes, AB 2005, 'Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy' , Chemical Communications (14) , pp. 1860-1862.

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Abstract

The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties in the micromolar range.

Item Type: Article
Themes: Subjects / Themes > Q Science > Q Science (General)
Subjects / Themes > Q Science > QD Chemistry
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemistry
Refereed: Yes
ISSN: 13597345
Depositing User: H Kenna
Date Deposited: 07 Aug 2007 14:02
Last Modified: 20 Aug 2013 16:45
URI: http://usir.salford.ac.uk/id/eprint/142

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