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Effects of silver sulphadiazine on the production of exoproteins by staphylococcus aureus

Edwards-Jones, V and Foster, HA 2002, 'Effects of silver sulphadiazine on the production of exoproteins by staphylococcus aureus' , Journal of Medical Microbiology, 51 (1) , pp. 50-55.

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Abstract

The effects of subinhibitory concentrations of silver sulphadiazine (AgSD) on exoprotein production in Staphylococcus aureus strains T1, T4, RN4282 and RN 4282agr were studied. AgSD markedly increased levels of toxic shock syndrome toxin (TSST)-1 in strains T4 and RN4282. This effect was independent of agr and AgSD restored TSST-1 production to the wild-type level in RN 4282agr. AgSD had no effect on enterotoxin A or coagulase activity in strains T1 or T4. Strain T4 produced enterotoxin C at high levels and no effect was observed with AgSD. AgSD repressed metalloprotease production in strain T4 but the overall protease activity remained the same. No change in proteolytic activities was seen in strain T1 with AgSD. Molecular mechanisms for these observations are discussed.

Item Type: Article
Themes: Subjects / Themes > Q Science > Q Science (General)
Subjects / Themes > R Medicine > R Medicine (General)
Subjects / Themes > Q Science > QR Microbiology
Health and Wellbeing
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
Journal or Publication Title: Journal of Medical Microbiology
Publisher: Society for General Microbiology
Refereed: Yes
ISSN: 00222615
Depositing User: H Kenna
Date Deposited: 07 Aug 2007 14:08
Last Modified: 20 Aug 2013 16:45
URI: http://usir.salford.ac.uk/id/eprint/144

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