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Predictors of depressive symptoms in persons with diabetic peripheral neuropathy: a longitudinal study

Vileikyte, L, Peyrot, M, Gonzalez, J, Rubin, R, Garrow, A, Stickings, D, Waterman, C and Ulbrecht, J 2009, 'Predictors of depressive symptoms in persons with diabetic peripheral neuropathy: a longitudinal study' , Diabetologia, 52 (7) , pp. 1265-1273.

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    Abstract

    The aim of the study was to determine whether diabetic peripheral neuropathy (DPN) is a risk factor for depressive symptoms and examine the potential mechanisms for this relationship. This longitudinal study (9 and 18 month followup) of 338 DPN patients (mean age 61 years; 71% male; 73% type 2 diabetes) examined the temporal relationships between DPN severity (mean±SD; neuropathy disability score [NDS], 7.4±2.2; mean vibration perception threshold, 41.5±9.5 V), DPN somatic experiences (symptoms and foot ulceration), DPN psychosocial consequences (restrictions in activities of daily living [ADL] and social selfperception)and the Hospital Anxiety and Depression subscale measuring depressive symptoms (HADS-D; mean 4.9±3.7). Controlling for baseline HADS-D and demographic/disease variables, NDS at baseline significantly predicted increased HADS-D over 18 months. This association was mediated by baseline unsteadiness, which was significantly associated with increased HADS-D. Baseline ADL restrictions significantly predicted increased HADS-D and partly mediated the association between baseline unsteadiness and change in HADS-D. Increased pain, unsteadiness and ADL restrictions from baseline to 9 months each significantly predicted increased HADS-D over 18 months. Change in social self-perception from baseline to 9 months significantly predicted increased HADS-D and partly mediated the relationships of change in unsteadiness and ADL restrictions with change in HADS-D. These results confirm that neuropathy is a risk factor for depressive symptoms because it generates pain and unsteadiness. Unsteadiness is the symptom with the strongest association with depression,and is linked to depressive symptoms by perceptions of diminished self-worth as a result of inability to perform social roles.

    Item Type: Article
    Uncontrolled Keywords: Activities of daily living, depressivesymptoms,diabetic peripheral neuropathy, longitudinal, social self-perception
    Themes: Subjects / Themes > R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
    Health and Wellbeing
    Schools: Colleges and Schools > College of Health & Social Care
    Colleges and Schools > College of Health & Social Care > School of Nursing, Midwifery, Social Work & Social Sciences > Centre for Social Justice Research
    Journal or Publication Title: Diabetologia
    Publisher: Springer Verlag
    Refereed: Yes
    ISSN: 0012-186X
    Funders: Diabetes UK, American Diabetes Association
    Depositing User: Users 47901 not found.
    Date Deposited: 26 Apr 2011 11:21
    Last Modified: 20 Aug 2013 17:51
    URI: http://usir.salford.ac.uk/id/eprint/14937

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