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Synthesis and evaluation of double bond substituted combretastatins

Hadfield, JA, Gaukroger, K, Hirst, N, Weston, AP, Lawrence, NJ and McGown, AT 2005, 'Synthesis and evaluation of double bond substituted combretastatins' , European Journal of Medicinal Chemistry, 40 (6) , pp. 529-541.

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Abstract

A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.

Item Type: Article
Uncontrolled Keywords: Combretastatin; Tubulin; Antimitotic
Themes: Subjects / Themes > Q Science > Q Science (General)
Subjects / Themes > Q Science > QD Chemistry
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: European Journal of Medicinal Chemistry
Publisher: Elsevier
Refereed: Yes
ISSN: 02235234
Depositing User: H Kenna
Date Deposited: 07 Aug 2007 14:57
Last Modified: 20 Aug 2013 16:45
URI: http://usir.salford.ac.uk/id/eprint/151

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