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Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers

Ruparelia, P, Cheow, HK, Evans, JW, Banney, L, Shankar, S, Szczepura, K, Swift, AE, Ballinger, JR, Hartman, NG, Chilvers, ER and Peters, AM 2008, 'Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers' , British Journal of Clinical Pharmacology, 65 (4) , pp. 611-614.

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    Abstract

    Aim - To explore inhaled technetium-99m-labelled hexakis-methoxy-isobutyl isonitrile (99mTc-sestamibi) for quantifying pulmonary P-glycoprotein(P-gp) expression. Methods - The elimination rate from the lungs of 99mTc-sestamibi was recorded scintigraphically for 30min following inhalation as an aerosol in healthy smokers, nonsmokers and patients with lung disease. Results - 99m Tc-sestamibi elimination rates [%min-1 (SD; P vs. healthy nonsmokers)] were: healthy nonsmokers, 0.43 (0.083); healthy smokers,0.19 (0.056; P < 0.001); chronic obstructive pulmonary disease patients, 0.26 (0.077; P < 0.001). Elimination rates in three patients with interstitial lung disease were not accelerated. Cconclusion - Cigarette smoke upregulates lung P-gp. 99mTc-sestamibi elimination in normal smokers could be used to test new P-gp modulators. The findings also have implications for inhaled drug delivery.

    Item Type: Article
    Uncontrolled Keywords: 99m Tc-sestamibi, aerosol, chronic obstructive pulmonary disease, lungs, P-glycoprotein, smoking
    Themes: Health and Wellbeing
    Schools: Colleges and Schools > College of Health & Social Care
    Colleges and Schools > College of Health & Social Care > School of Health Sciences
    Journal or Publication Title: British Journal of Clinical Pharmacology
    Publisher: Wiley-Blackwell
    Refereed: Yes
    ISSN: 0306-5251
    Depositing User: RH Shuttleworth
    Date Deposited: 16 May 2011 11:25
    Last Modified: 18 Aug 2014 12:03
    URI: http://usir.salford.ac.uk/id/eprint/15791

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