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Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers

Ruparelia, P, Cheow, HK, Evans, JW, Banney, L, Shankar, S, Szczepura, K, Swift, AE, Ballinger, JR, Hartman, NG, Chilvers, ER and Peters, AM 2008, 'Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers' , British Journal of Clinical Pharmacology, 65 (4) , pp. 611-614.

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Abstract

Aim - To explore inhaled technetium-99m-labelled hexakis-methoxy-isobutyl isonitrile (99mTc-sestamibi) for quantifying pulmonary P-glycoprotein(P-gp) expression. Methods - The elimination rate from the lungs of 99mTc-sestamibi was recorded scintigraphically for 30min following inhalation as an aerosol in healthy smokers, nonsmokers and patients with lung disease. Results - 99m Tc-sestamibi elimination rates [%min-1 (SD; P vs. healthy nonsmokers)] were: healthy nonsmokers, 0.43 (0.083); healthy smokers,0.19 (0.056; P < 0.001); chronic obstructive pulmonary disease patients, 0.26 (0.077; P < 0.001). Elimination rates in three patients with interstitial lung disease were not accelerated. Cconclusion - Cigarette smoke upregulates lung P-gp. 99mTc-sestamibi elimination in normal smokers could be used to test new P-gp modulators. The findings also have implications for inhaled drug delivery.

Item Type: Article
Uncontrolled Keywords: 99m Tc-sestamibi, aerosol, chronic obstructive pulmonary disease, lungs, P-glycoprotein, smoking
Themes: Health and Wellbeing
Schools: Colleges and Schools > College of Health & Social Care
Colleges and Schools > College of Health & Social Care > School of Health Sciences
Journal or Publication Title: British Journal of Clinical Pharmacology
Publisher: Wiley-Blackwell
Refereed: Yes
ISSN: 0306-5251
Depositing User: RH Shuttleworth
Date Deposited: 16 May 2011 10:25
Last Modified: 18 Aug 2014 11:03
URI: http://usir.salford.ac.uk/id/eprint/15791

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