Botulinum toxin treatment of spasticity in diplegic cerebral palsy: a randomised, double-blind, placebo-controlled, dose-ranging study
Baker, RJ, Jasinski, M, Maciag-Tymecka, I, Michalowska-Mrozek, J, Bonikowski, M, Carr, L, MacLean, J, Lin, JP, Lynch, B, Theologis, T, Wendorff, J, Eunson, P and Cosgrove, A 2002, 'Botulinum toxin treatment of spasticity in diplegic cerebral palsy: a randomised, double-blind, placebo-controlled, dose-ranging study' , Developmental Medicine and Child Neurology, 44 (10) , pp. 666-675.
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This study evaluated the efficacy and safety of three doses of botulinum toxin A (BTX-A; Dysport®) in 125 patients (mean age 5.2 years, SD 2; 54% male)with dynamic equinus spasticity during walking. Participants were randomized to receive Dysport (10, 20, or 30 units/kg) or placebo to the gastrocnemius muscle of both legs. Muscle length was calculated from electrogoniometric measurements and the change in the dynamic component of gastrocnemius shortening at four weeks was prospectively identified as the primary outcome measure. All treatment groups showed statistically significant decreases in dynamic component compared with placebo at 4 weeks. Mean improvement in dynamic component was most pronounced in the 20 units/kg group, being equivalent to an increase in dorsiflexion with the knee extended at 19°, and was still present at 16 weeks. The safety profile of the toxin appears satisfactory.
|Themes:||Health and Wellbeing|
|Schools:||Colleges and Schools > College of Health & Social Care
Colleges and Schools > College of Health & Social Care > School of Health Sciences
|Journal or Publication Title:||Developmental Medicine and Child Neurology|
|Publisher:||Cambridge University Press|
|Depositing User:||RH Shuttleworth|
|Date Deposited:||07 Jul 2011 09:15|
|Last Modified:||20 Aug 2013 16:59|
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