Skip to the content

Botulinum toxin treatment of spasticity in diplegic cerebral palsy: a randomised, double-blind, placebo-controlled, dose-ranging study

Baker, RJ, Jasinski, M, Maciag-Tymecka, I, Michalowska-Mrozek, J, Bonikowski, M, Carr, L, MacLean, J, Lin, JP, Lynch, B, Theologis, T, Wendorff, J, Eunson, P and Cosgrove, A 2002, 'Botulinum toxin treatment of spasticity in diplegic cerebral palsy: a randomised, double-blind, placebo-controlled, dose-ranging study' , Developmental Medicine and Child Neurology, 44 (10) , pp. 666-675.

[img]
Preview
PDF - Published Version
Download (96kB) | Preview

    Abstract

    This study evaluated the efficacy and safety of three doses of botulinum toxin A (BTX-A; Dysport®) in 125 patients (mean age 5.2 years, SD 2; 54% male)with dynamic equinus spasticity during walking. Participants were randomized to receive Dysport (10, 20, or 30 units/kg) or placebo to the gastrocnemius muscle of both legs. Muscle length was calculated from electrogoniometric measurements and the change in the dynamic component of gastrocnemius shortening at four weeks was prospectively identified as the primary outcome measure. All treatment groups showed statistically significant decreases in dynamic component compared with placebo at 4 weeks. Mean improvement in dynamic component was most pronounced in the 20 units/kg group, being equivalent to an increase in dorsiflexion with the knee extended at 19°, and was still present at 16 weeks. The safety profile of the toxin appears satisfactory.

    Item Type: Article
    Themes: Health and Wellbeing
    Schools: Colleges and Schools > College of Health & Social Care
    Colleges and Schools > College of Health & Social Care > School of Health Sciences
    Journal or Publication Title: Developmental Medicine and Child Neurology
    Publisher: Cambridge University Press
    Refereed: Yes
    ISSN: 0012-1622
    Depositing User: RH Shuttleworth
    Date Deposited: 07 Jul 2011 10:15
    Last Modified: 20 Aug 2013 17:59
    URI: http://usir.salford.ac.uk/id/eprint/16568

    Actions (login required)

    Edit record (repository staff only)

    Downloads per month over past year

    View more statistics