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The effect of botulinum toxin A on gastrocnemius length: magnitude and duration of response

Eames, NWA, Baker, RJ, Hill, N, Graham, K, Taylor, T and Cosgrove, A 1999, 'The effect of botulinum toxin A on gastrocnemius length: magnitude and duration of response' , Developmental Medicine and Child Neurology, 41 (4) , pp. 226-232.

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    Abstract

    Thirty-nine ambulant children (22 with hemiplegia, 17 with diplegia) with spastic cerebral palsy receiving isolated gastrocnemius muscle injection with botulinum toxin A were studied prospectively. The children had a mean age of 6 years(range 3 to 13 years). Measurement of gastrocnemius muscle length was used to estimate the dynamic component of each child’s spasticity and to quantify the response. There was a strong correlation between the dynamic component of spasticity before injection and the corresponding magnitude of the response after injection. Children undergoing repeated injections showed similar correlations. A strong correlation was found between the duration of response and the dynamic component. Children with hemiplegia showed twice the duration for a given dynamic component compared with those with diplegia when injected with the same total dose per unit body weight. Long-term lengthening did not occur for the cohort, although some patients showed a response at a 12-month follow-up. By delaying shortening, the injections may have a role in delaying the need for surgery. Injections were well tolerated with few side effects.

    Item Type: Article
    Themes: Health and Wellbeing
    Schools: Colleges and Schools > College of Health & Social Care
    Colleges and Schools > College of Health & Social Care > School of Health Sciences
    Journal or Publication Title: Developmental Medicine and Child Neurology
    Publisher: Cambridge University Press
    Refereed: Yes
    ISSN: 0012-1622
    Depositing User: RH Shuttleworth
    Date Deposited: 07 Jul 2011 11:37
    Last Modified: 20 Aug 2013 18:00
    URI: http://usir.salford.ac.uk/id/eprint/16590

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