Bryant, CH, Kemp, GJL and Cvijovic, M 2006, 'A first step towards learning which uORFs regulate gene expression' , Journal of Integrative Bioinformatics, 3 (2) , p. 31.
We have taken a first step towards learning which upstream Open Reading Frames (uORFs) regulate gene expression (i.e., which uORFs are functional) in the yeast Saccharomyces cerevisiae. We do this by integrating data from several resources and combining a bioinformatics tool, ORF Finder, with a machine learning technique, Inductive Logic Programming (ILP). Here, we report the challenge of using ILP as part of this integrative system, in order to automatically generate a model that identifies functional uORFs. Our method makes searching for novel functional uORFs more efficient than random sampling. An attempt has been made to predict novel functional uORFs using our method. Some preliminary evidence that our model may be biologically meaningful is presented.
|Additional Information:||Paper presented at the 3rd International Workshop on Integrative Bioinformatics, 2006|
|Themes:||Subjects / Themes > Q Science > QA Mathematics > QA075 Electronic computers. Computer science
Subjects / Themes > Q Science > QH Natural history > QH301 Biology
Subjects outside of the University Themes
|Schools:||Schools > School of Computing, Science and Engineering
Schools > School of Computing, Science and Engineering > Salford Innovation Research Centre (SIRC)
|Journal or Publication Title:||Journal of Integrative Bioinformatics|
|Publisher:||Bielefeld University, Germany|
|Depositing User:||Dr Chris H. Bryant|
|Date Deposited:||16 Feb 2009 14:07|
|Last Modified:||01 Dec 2015 00:00|
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