Functional genomic hypothesis generation and experimentation by a robot scientist
King, RD, Whelan, KE, Jones, FM, Reiser, PGK, Bryant, CH, Muggleton, SH, Kell, DB and Oliver, SG 2004, 'Functional genomic hypothesis generation and experimentation by a robot scientist' , Nature, 427 (6971) , pp. 247-252.Full text not available from this repository.
The question of whether it is possible to automate the scientific process is of both great theoretical interest and increasing practical importance because, in many scientific areas, data are being generated much faster than they can be effectively analysed. We describe a physically implemented robotic system that applies techniques from artificial intelligence to carry out cycles of scientific experimentation. The system automatically originates hypotheses to explain observations, devises experiments to test these hypotheses, physically runs the experiments using a laboratory robot, interprets the results to falsify hypotheses inconsistent with the data, and then repeats the cycle. Here we apply the system to the determination of gene function using deletion mutants of yeast (Saccharomyces cerevisiae) and auxotrophic growth experiments. We built and tested a detailed logical model (involving genes, proteins and metabolites) of the aromatic amino acid synthesis pathway. In biological experiments that automatically reconstruct parts of this model, we show that an intelligent experiment selection strategy is competitive with human performance and significantly outperforms, with a cost decrease of 3-fold and 100-fold (respectively), both cheapest and random-experiment selection.
|Uncontrolled Keywords:||robotics, active learning, inductive logic programming|
|Themes:||Subjects / Themes > Q Science > Q Science (General)|
Subjects outside of the University Themes
|Schools:||Colleges and Schools > College of Science & Technology|
Colleges and Schools > College of Science & Technology > School of Computing, Science and Engineering
Colleges and Schools > College of Science & Technology > School of Computing, Science and Engineering > Data Mining and Pattern Recognition Research Centre
|Journal or Publication Title:||Nature|
|Publisher:||Nature Publishing Group|
|Depositing User:||Dr Chris H. Bryant|
|Date Deposited:||16 Feb 2009 14:25|
|Last Modified:||27 Sep 2011 12:26|
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