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In-vitro susceptibility of hydatid cysts of echinococcus granulosus to nitric oxide and the effect of the laminated layer on nitric oxide production

Steers, NRJ, Rogan, MT and Heath, S 2001, 'In-vitro susceptibility of hydatid cysts of echinococcus granulosus to nitric oxide and the effect of the laminated layer on nitric oxide production' , Parasite Immunology, 23 (8) , pp. 411-417.

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Abstract

Murine hydatid cysts of Echinococcus granulosus were incubated in vitro in the presence of nitric oxide produced from S-nitroso-N-acetylpenicillamine (SNAP) or interferon-gamma activated peritoneal macrophages. In both situations, evidence of cyst damage and death was observed by microscopy in over 77% of cysts after 3 days, indicating that intact hydatid cysts could be susceptible to a Th1 driven macrophage attack. A crude extract of the laminated layer from cysts was found to be able to reduce the production of nitric oxide from activated macrophages in vitro and in vivo and this may have been due to phagocytosis of laminated layer fragments by the macrophages. The results indicate that, although cysts may be susceptible to the effects of nitric oxide, the laminated layer may be involved in downregulating nitric oxide production.

Item Type: Article
Uncontrolled Keywords: Echinococcus granulosus, nitric oxide, macrophage, reduction
Themes: Subjects / Themes > Q Science > Q Science (General)
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Parasite Immunology
Publisher: Blackwell Publishing
Refereed: Yes
ISSN: 01419838
Depositing User: H Kenna
Date Deposited: 08 Aug 2007 12:32
Last Modified: 20 Aug 2013 16:45
URI: http://usir.salford.ac.uk/id/eprint/176

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