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A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis?

Anthony, BJ, Allen, J, Li, Y and McManus, D 2012, 'A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis?' , PPAR research, 2012 , p. 128068.

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    Abstract

    Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages. Interestingly, helminth infections, such as the schistosome blood flukes that cause schistosomiasis, are characterised by a Th2 response and the accumulation of alternative activated macrophages. This would suggest that at some level, PPARs could have a role in the modulation of the immune response in schistosomiasis. This paper discusses possible areas where PPARs could have a role in this disease.

    Item Type: Article
    Themes: Health and Wellbeing
    Schools: Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
    Journal or Publication Title: PPAR research
    Publisher: Hindawi Publishing Corporation
    Refereed: Yes
    ISSN: 1687-4765
    Depositing User: JT Allen
    Date Deposited: 06 Oct 2011 10:10
    Last Modified: 23 Sep 2013 15:21
    URI: http://usir.salford.ac.uk/id/eprint/17904

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