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Circulating regulatory T cells in endometrial cancer: a role for age and menopausal status

Sawan, S, Burt, D, Stern, P, Holland, C and Elkord, E 2011, 'Circulating regulatory T cells in endometrial cancer: a role for age and menopausal status' , Immunological Investigations - A Journal of Molecular and Cellular Immunology, 40 (1) , pp. 62-75.

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Abstract

Regulatory T cells (Treg) are a sub-population of T cells that suppress self-reactivity and are implicated in immune tolerance towards malignant cells. Circulating Treg cells are increased in several cancers. In endometrial cancer Treg cells have been investigated only in tumour tissues and, in contrast to some other tumours, fewer Treg cells were reported in endometrial cancer compared with benign controls. Flow cytometry was used to determine the frequency of circulating Treg cells in women undergoing hysterectomy for either endometrial cancer (n = 24) or non- cancer-related conditions (n = 21). Circulating Treg cells were more abundant in women with cancer compared to those without (4.68% vs. 3.66%, p = 0.05, Mann-Whitney test). This relationship disappeared, however, when only data from post-menopausal women were included in the analysis. Mean Treg cell frequency was 4.65% in postmenopausal women with cancer (n = 23) and 4.73% in postmenopausal controls (n = 5) (p = 0.9). In women without cancer we found that mean Treg cell frequency was higher in postmenopausal women (4.73%, n = 5) in comparison to premenopausal controls (3.33%, n = 16) (p = 0.02). These results suggest that the increased proportion of Treg cells seen in endometrial cancer patients might be, at least in part, attributed to their postmenopausal status or age.

Item Type: Article
Themes: Health and Wellbeing
Schools: Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Journal or Publication Title: Immunological Investigations - A Journal of Molecular and Cellular Immunology
Publisher: Informa Healthcare
Refereed: Yes
ISSN: 0882-0139
Depositing User: E Elkord
Date Deposited: 11 Oct 2011 15:31
Last Modified: 20 Aug 2013 17:13
URI: http://usir.salford.ac.uk/id/eprint/18232

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