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Novel therapeutic strategies by regulatory T cells in allergy

Elkord, E 2008, 'Novel therapeutic strategies by regulatory T cells in allergy' , in: T Cell Regulation in Allergy, Asthma and Atopic Skin Diseases , Karger, Chemical Immunology and Allergy, pp. 150-157.

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    Abstract

    Natural CD4+CD25+FoxP3+ regulatory T cells (Treg) actively suppress physiological and pathological responses, therefore playing a critical role in controlling peripheral tolerance to self antigens and maintaining immune homeostasis. In normal individuals, natural Treg and interleukin- 10-secreting Treg are able to suppress Th2 responses to allergens, whereas lower levels of Treg or defect in their functionality have been described as potential mechanisms for inducing allergic diseases. In animal models, adoptive transfer of CD4+CD25+Treg has been shown as a promising strategy for preventing or treating allergic disorders. Recent studies show that induction of Treg activity is associated with suppression of allergic responses in allergic patients treated with specific immunotherapy. Herein, I review the potential of Treg as exciting targets for developing new immunotherapeutic strategies for treating allergic diseases.

    Item Type: Book Section
    Editors: Blaser, K
    Themes: Subjects outside of the University Themes
    Schools: Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
    Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
    Publisher: Karger
    Refereed: Yes
    Depositing User: E Elkord
    Date Deposited: 13 Oct 2011 09:53
    Last Modified: 20 Aug 2013 18:13
    URI: http://usir.salford.ac.uk/id/eprint/18276

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