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Role of regulatory T cells in allergy: implications for therapeutic strategy

Elkord, E 2006, 'Role of regulatory T cells in allergy: implications for therapeutic strategy' , Inflammation and Allergy - Drug Targets, 5 (4) , pp. 211-217.

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Abstract

The interest in regulatory T cells (Tregs) has been revived following the discovery of developing multiorgan autoimmune diseases as a result of depleting CD4+CD25+ T cells from mice. The importance of Tregs is being recognized in various clinical fields such as tumor and microbial immunities, transplantation and allergy. Prevalence of allergic diseases such as asthma, atopic dermatitis and rhinitis is significantly increasing worldwide. A better understanding of the mechanisms of T-cell regulation in allergic diseases may help in developing more effective therapeutic strategies. The well-known role of Tregs in preventing autoimmune diseases indicates that these important cells might be involved in prevention of allergy, and allergic diseases are associated with a low frequency and/or an impaired function of Tregs. Recent data show that natural CD4+CD25+ Tregs and interleukin (IL)-10-producing Tregs are normally able to suppress Th2 responses to allergens, while such suppression is diminished in allergic conditions. In this review, I summarize the role of Tregs in allergic diseases and discuss the possibility of manipulating these cells for treating allergic diseases.

Item Type: Article
Themes: Health and Wellbeing
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Journal or Publication Title: Inflammation and Allergy - Drug Targets
Publisher: Bentham Science Publishers
Refereed: Yes
ISSN: 1871-5281
Depositing User: E Elkord
Date Deposited: 13 Oct 2011 09:56
Last Modified: 20 Aug 2013 17:13
URI: http://usir.eprints.org/id/eprint/18287

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