Burr, SJ, Mselati, A and Thomas, EW 2003, 'Photochemical DNA cleavage by a Berenil analog' , Tetrahedron Letters, 44 (39) , pp. 7307-7309.

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Abstract

Berenil [bis(4-amidinophenyl)1,3-triazene] is a photostable DNA-binding ligand. We describe here the synthesis of N-(3-hydroxypropyl)-Berenil, which in contrast to Berenil is photosensitive to 360 nm irradiation, behaving as a caged diazonium salt. The 4-amidinobenzenediazonium fragment produced by photolysis induces DNA modification and cleavage.

Item Type:	Article
Themes:	Subjects / Themes > Q Science > Q Science (General) Subjects outside of the University Themes
Schools:	Colleges and Schools > College of Science & Technology Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Journal or Publication Title:	Tetrahedron Letters
Publisher:	Elsevier
Refereed:	Yes
ISSN:	00404039
Depositing User:	H Kenna
Date Deposited:	08 Aug 2007 13:45
Last Modified:	27 Sep 2011 12:27
URI:	http://usir.salford.ac.uk/id/eprint/184

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