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Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent

Wilkinson, JA, Rossington, SB, Leonard, J and Hussain, N 2004, 'Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent' , Tetrahedron Letters, 45 (28) , pp. 5481-5483.

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Abstract

Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee. The best results were obtained in allylation reactions but methylation, ethylation, benzylation and trimethylsilylation have all been carried out with acceptable ee.

Item Type: Article
Uncontrolled Keywords: Asymmetric, alkylation, diarylmethane, sparteine
Themes: Subjects / Themes > Q Science > Q Science (General)
Subjects / Themes > Q Science > QD Chemistry
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Tetrahedron Letters
Publisher: Elsevier
Refereed: Yes
ISSN: 00404039
Depositing User: H Kenna
Date Deposited: 08 Aug 2007 15:04
Last Modified: 20 Aug 2013 16:45
URI: http://usir.salford.ac.uk/id/eprint/188

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