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Entropy-based epistasy search in SNP case-control studies

Manzour, A and Saraee, M 2007, Entropy-based epistasy search in SNP case-control studies , in: Fuzzy Systems and Knowledge Discovery, 2007. FSKD 2007., August 28-30 2007, Haikou, China.

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Abstract

The purpose of gene mapping is to identify the causal genetic regions of a specific phenotype mainly a complex disease. Most complex diseases are believed to have multiple contributing loci often having subtle patterns which make them fairly difficult to find in large datasets. We present and discuss a new criterion called conditional mutual information for association mapping and compare it to the previous criterion which is mutual information from different aspects. Furthermore, algorithms are proposed to find relevance chains. The proposed algorithms are especially in favor of diseases having almost equally contributing regions known as being epistatic. These algorithms are applied to both simulated and real data. The real data represents the genotype-phenotype values for AMD disease. Proposed relevance-chain algorithms have detected some highly associated markers with AMD. C# source files for relevance-chains algorithm are freely available at https://www. sharemation. com/amanzour.

Item Type: Conference or Workshop Item (Paper)
Themes: Health and Wellbeing
Schools: Colleges and Schools > College of Science & Technology > School of Computing, Science and Engineering > Data Mining and Pattern Recognition Research Centre
Journal or Publication Title: Proceedings of Fourth International Conference on Fuzzy Systems and Knowledge Discovery, 2007. FSKD 2007.
Refereed: Yes
Depositing User: Dr Mo Saraee
Date Deposited: 04 Nov 2011 11:04
Last Modified: 20 Aug 2013 17:17
URI: http://usir.salford.ac.uk/id/eprint/18850

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