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Asymmetric alkylation of diarylmethane derivatives

Wilkinson, JA, Rossington, SB, Ducki, S, Leonard, J and Hussain, N 2006, 'Asymmetric alkylation of diarylmethane derivatives' , Tetrahedron, 62 (8) , pp. 1833-1844.

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Abstract

Deprotonation–alkylation of prochiral diarylmethane substrates using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee. A variety of enantioselective alkylations, silylations and stannylations have been performed on four different diarylmethanes. Surrogates for (+)-sparteine have also been applied in this study including a novel surrogate.

Item Type: Article
Uncontrolled Keywords: Asymmetric, alkylation, diarylmethane, sparteine
Themes: Subjects / Themes > Q Science > Q Science (General)
Subjects / Themes > Q Science > QD Chemistry
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Tetrahedron
Publisher: Elsevier
Refereed: Yes
ISSN: 00404020
Depositing User: H Kenna
Date Deposited: 08 Aug 2007 15:24
Last Modified: 20 Aug 2013 16:45
URI: http://usir.salford.ac.uk/id/eprint/191

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