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Delineating anaplasma phagocytophilum ecotypes in coexisting, discrete enzootic cycles

Bown, K, Lambin, X, Ogden, NH, Begon, M, Telford, G, Woldehiwet, Z and Birtles, RJ 2009, 'Delineating anaplasma phagocytophilum ecotypes in coexisting, discrete enzootic cycles' , Emerging Infectious Diseases, 15 (12) .

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    Abstract

    The emerging tick-borne pathogen Anaplasma phagocytophilum is under increasing scrutiny for the existence of subpopulations that are adapted to different natural cycles. Here, we characterized the diversity of A. phagocytophilum genotypes circulating in a natural system that includes multiple hosts and at least 2 tick species, Ixodes ricinus and the small mammal specialist I. trianguliceps. We encountered numerous genotypes, but only 1 in rodents, with the remainder limited to deer and host-seeking I. ricinus ticks. The absence of the rodent-associated genotype from host-seeking I. ricinus ticks was notable because we demonstrated that rodents fed a large proportion of the I. ricinus larval population and that these larvae were abundant when infections caused by the rodent-associated genotype were prevalent. These observations are consistent with the conclusion that genotypically distinct subpopulations of A. phagocytophilum are restricted to coexisting but separate enzootic cycles and suggest that this restriction may result from specific vector compatibility.

    Item Type: Article
    Themes: Subjects outside of the University Themes
    Schools: Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
    Journal or Publication Title: Emerging Infectious Diseases
    Publisher: National Center for Infectious Diseases
    Refereed: Yes
    ISSN: 10806040
    Depositing User: Users 29196 not found.
    Date Deposited: 20 Dec 2011 12:17
    Last Modified: 20 Aug 2013 18:19
    URI: http://usir.salford.ac.uk/id/eprint/19237

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