Hadfield, JA, Hirst, N, Mcgown, A, Lawrence, NJ and Gaukroger, K 2012, 'A practical radiosynthesis of a tritium-labelled fluoro combretastatin' , Journal of Labelled Compounds and Radiopharmaceuticals, 55 (8) , pp. 303-306.
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Zybrestat (combretastatin A-4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent and a radiolabelled version would enable further understanding of its biological activities. Herein is described the synthesis of a tritiated fluorinated analogue of Zybrestat.
|Themes:||Health and Wellbeing|
|Schools:||Schools > School of Environment and Life Sciences|
|Journal or Publication Title:||Journal of Labelled Compounds and Radiopharmaceuticals|
|Publisher:||John Wiley & Sons|
|Funders:||Cancer Research UK, Association for International Cancer Research (AICR)|
|Depositing User:||JA Hadfield|
|Date Deposited:||31 May 2012 08:50|
|Last Modified:||05 Apr 2016 18:07|
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