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A practical radiosynthesis of a tritium-labelled fluoro combretastatin

Hadfield, JA, Hirst, N, Mcgown, A, Lawrence, NJ and Gaukroger, K 2012, 'A practical radiosynthesis of a tritium-labelled fluoro combretastatin' , Journal of Labelled Compounds and Radiopharmaceuticals, 55 (8) , pp. 303-306.

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Zybrestat (combretastatin A-4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent and a radiolabelled version would enable further understanding of its biological activities. Herein is described the synthesis of a tritiated fluorinated analogue of Zybrestat.

Item Type: Article
Themes: Health and Wellbeing
Schools: Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
Journal or Publication Title: Journal of Labelled Compounds and Radiopharmaceuticals
Publisher: John Wiley & Sons
Refereed: Yes
ISSN: 0362-4803
Related URLs:
Funders: Cancer Research UK, Association for International Cancer Research (AICR)
Depositing User: JA Hadfield
Date Deposited: 31 May 2012 08:50
Last Modified: 26 Jan 2014 19:54

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