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A practical radiosynthesis of a tritium-labelled fluoro combretastatin

Hadfield, JA, Hirst, N, Mcgown, A, Lawrence, NJ and Gaukroger, K 2012, 'A practical radiosynthesis of a tritium-labelled fluoro combretastatin' , Journal of Labelled Compounds and Radiopharmaceuticals, 55 (8) , pp. 303-306.

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    Abstract

    Zybrestat (combretastatin A-4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent and a radiolabelled version would enable further understanding of its biological activities. Herein is described the synthesis of a tritiated fluorinated analogue of Zybrestat.

    Item Type: Article
    Themes: Health and Wellbeing
    Schools: Colleges and Schools > College of Science & Technology > School of Environment and Life Sciences
    Journal or Publication Title: Journal of Labelled Compounds and Radiopharmaceuticals
    Publisher: John Wiley & Sons
    Refereed: Yes
    ISSN: 0362-4803
    Related URLs:
    Funders: Cancer Research UK, Association for International Cancer Research (AICR)
    Depositing User: JA Hadfield
    Date Deposited: 31 May 2012 09:50
    Last Modified: 26 Jan 2014 19:54
    URI: http://usir.salford.ac.uk/id/eprint/22778

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