Fraser, C, Power, ML, Hamdy, S, Rothwell, J, Hobday, D, Hollander, I, Tyrrell, PJ, Hobson, A, Williams, S and Thompson, DG 2002, 'Driving plasticity in human adult motor cortex is associated with improved motor function after brain injury' , Neuron, 34 (5) , pp. 831-40.Full text not available from this repository.
Changes in somatosensory input can remodel human cortical motor organization, yet the input characteristics that promote reorganization and their functional significance have not been explored. Here we show with transcranial magnetic stimulation that sensory-driven reorganization of human motor cortex is highly dependent upon the frequency, intensity, and duration of stimulus applied. Those patterns of input associated with enhanced excitability (5 Hz, 75% maximal tolerated intensity for 10 min) induce stronger cortical activation to fMRI. When applied to acutely dysphagic stroke patients, swallowing corticobulbar excitability is increased mainly in the undamaged hemisphere, being strongly correlated with an improvement in swallowing function. Thus, input to the human adult brain can be programmed to promote beneficial changes in neuroplasticity and function after cerebral injury.
|Themes:||Subjects / Themes > R Medicine > R Medicine (General)
Health and Wellbeing
|Schools:||Schools > School of Environment and Life Sciences|
|Journal or Publication Title:||Neuron|
|Depositing User:||H Kenna|
|Date Deposited:||10 Aug 2007 14:34|
|Last Modified:||01 Dec 2015 00:03|
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