A pilot study to assess the value of magnetic resonance imaging in diabetic patients
Esmail, Z 2010, A pilot study to assess the value of magnetic resonance imaging in diabetic patients , PhD thesis, Salford : University of Salford.
Restricted to Repository staff only until 31 July 2016.
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Purpose: To assess the feasibility of multiple-bolus dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in the pancreas; to optimize the analysis; and to investigate the application of the method to glucose challenge in type II diabetes. This has the benefit of using MRI as a diagnostic tool for investigating diabetes Type II and developing diabetes medications. Materials and Method: The study was approved by the Local Research Ethics Committee and all subjects gave written informed consent written informed consent was obtained. Method 1: Three non-diabetic volunteers (two women aged 26 and 31 years respectively and one man aged 41 years) underwent 3D RF-spoiled fast field echo-GRE, non enhanced axial planes to optimize and develop high resolution pancreatic MR imaging protocol using 3.0T MR scanner. Qualitative and quantitative assessments were done to measure the image quality of the resultant images, and statistical significances for the pancreas and the surrounding organs using different MR imaging pulse sequences were calculated using an analysis of variance. Method 2: Imaging was carried out using a 1.5T MR imaging system. DCE MR with a 3D RF-spoiled fast field echo (spoiled gradient echo (GRE)) axial planes was used to assess pancreatic microcirculation in subjects with and those without type II diabetes (1 female, 4 male; mean age 56.4 years; range, 31-68 years) and (6 female , 5 male; mean age 24.7 years; range 24-54 years) respectively. The perfusion studies were done in baseline and under glucose challenge on both groups. Microcirculatory semi-quantitative parameter, the area under the first 60s of the contrast agent concentration curve (lAUCeo) was calculated on avoxel-by-voxel basis within the defined 3D ROIs, were compared between the groups with and without glucose challenge by using paired t-test. Results: Method 1: The resulting images were rated to be of low quality (SNR, CNR) and the images were degraded by image artefacts which negatively affected the visual appearance of images (qualitative) and the TI relaxation values of the pancreas tissue (quantitative). Reaching the upper SAR limits quickly and magnetic field inhomogeneity also affected the quality of the pancreas image. Hence it was decided to transfer the study to lower field 1.5T MR scanner. Method 2: Significant differences in perfusion parameters (IAUC60) between the two pancreatic regions were observed (P < .05) where the IAUC60 reading was higher at the tail in non diabetic subjects (^=0.001). A significant increase in pancreatic perfusion IAUC60 was observed between the tail regions before and after glucose administration (P= 0.003). Patients with diabetes had a significantly lower IAUC60 in the tail region compared with patients without diabetes during glucose challenge (P= 0.01). Conclusion: Multiple bolus DCE-MRI is feasible in the pancreas as it enables noninvasive quantification of regional pancreatic perfusion in non-diabetic and diabetic type II under glucose challenge. This could greatly aid the diagnosis, staging, and treatment efficiency of this disease.
|Item Type:||Thesis (PhD)|
|Contributors:||Hogg, P (Supervisor) and Mackay, SJ (Supervisor)|
|Schools:||Schools > School of Humanities, Languages & Social Sciences|
|Depositing User:||Institutional Repository|
|Date Deposited:||03 Oct 2012 13:34|
|Last Modified:||30 Nov 2015 23:36|
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