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Novel therapeutic strategies to counter pseudomonas aeruginosa infections

Fothergill, J, Winstanley, C and James, C 2012, 'Novel therapeutic strategies to counter pseudomonas aeruginosa infections' , Expert Reviews of Anti Infective Therapy, 10 (2) , pp. 219-235.

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Abstract

Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsic multidrug resistance and has a tremendous capacity to acquire further resistance mechanisms. During chronic infection, the bacterium can form a protective biofilm therefore reducing the efficacy of existing antibiotics. P. aeruginosa also harbors an impressive range of virulence factors, many of which are controlled by the quorum-sensing system. Several novel therapeutics are under investigation such as those directed against biofilm formation and quorum-sensing systems along with bacteriophages and immunotherapies. Recent advances in next-generation sequencing and comparative genomics have opened the door to a new wave of smart drug design that could revolutionize P. aeruginosa treatment options.

Item Type: Article
Themes: Health and Wellbeing
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Expert Reviews of Anti Infective Therapy
Publisher: Expert Reviews Ltd
Refereed: Yes
ISSN: 1478-7210
Related URLs:
Funders: The Wellcome Trust, The NIHR School for Social Care Research (SSCR)
Depositing User: Dr Chloe James
Date Deposited: 21 Mar 2013 17:04
Last Modified: 04 Feb 2014 14:38
URI: http://usir.salford.ac.uk/id/eprint/28484

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