Fothergill, J, Winstanley, C and James, C 2012, 'Novel therapeutic strategies to counter pseudomonas aeruginosa infections' , Expert Reviews of Anti Infective Therapy, 10 (2) , pp. 219-235.
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Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsic multidrug resistance and has a tremendous capacity to acquire further resistance mechanisms. During chronic infection, the bacterium can form a protective biofilm therefore reducing the efficacy of existing antibiotics. P. aeruginosa also harbors an impressive range of virulence factors, many of which are controlled by the quorum-sensing system. Several novel therapeutics are under investigation such as those directed against biofilm formation and quorum-sensing systems along with bacteriophages and immunotherapies. Recent advances in next-generation sequencing and comparative genomics have opened the door to a new wave of smart drug design that could revolutionize P. aeruginosa treatment options.
|Themes:||Health and Wellbeing|
|Schools:||Schools > School of Environment and Life Sciences > Biomedical Research Centre|
|Journal or Publication Title:||Expert Reviews of Anti Infective Therapy|
|Publisher:||Expert Reviews Ltd|
|Funders:||The Wellcome Trust, The NIHR School for Social Care Research (SSCR)|
|Depositing User:||Dr Chloe James|
|Date Deposited:||21 Mar 2013 17:04|
|Last Modified:||04 Feb 2014 14:38|
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