Varghese, S, Elfakhri, SO, Sheel, DW, Sheel, P, Bolton, FJ and Foster, HA 2013, 'Novel antibacterial silver-silica surface coatings prepared by chemical vapour deposition for infection control' , Journal of Applied Microbiology, 115 (5) , pp. 1107-1116.
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Aims: Environmental contamination plays an important role in the transmission of infections, especially healthcare-associated infections. Disinfection transiently reduces contamination, but surfaces can rapidly become re-contaminated. Antimicrobial surfaces may partially overcome that limitation. The antimicrobial activity of novel surface coatings containing silver and silica prepared using a ﬂame-assisted chemical vapour deposition method on both glass and ceramic tiles was investigated. Methods and Results: Antimicrobial activity against a variety of bacteria including recent clinical isolates was investigated based on the BS ISO 22196:2007 Plastics – Measurement of antibacterial activity on plastics surfaces, British Standards Institute, London, method. Activity on natural contamination in an in use test in a toilet facility was also determined. Activity on standard test strains gave a log10 reduction of ﬁve after 1–4 h. The hospital isolates were more resistant, but MRSA was reduced by a log10 reduction factor of >5 after 24 h. Activity was maintained after simulated ageing and washing cycles. Contamination in situ was reduced by >99�9% after 4 months. Activity was inhibited by protein, but, although this could be overcome by increasing the amount of silver in the ﬁlms, this reduced the hardness of the coating. Conclusions: The coatings had a good activity against standard test strains. Clinical isolates were killed more slowly but were still sensitive. The optimum composition for use therefore needs to be a balance between activity and durability. Signiﬁcance and Impact of the Study: The coatings may have applications in health care by maintaining a background antimicrobial activity between standard cleaning and disinfection regimes. They may also have applications in other areas where reduction in microbial contamination is important, for example, in the food industry.
|Schools:||Schools > School of Environment and Life Sciences|
|Journal or Publication Title:||Journal of Applied Microbiology|
|Funders:||Funder not known|
|Depositing User:||S Rafiq|
|Date Deposited:||12 Sep 2014 14:57|
|Last Modified:||05 Apr 2016 18:17|
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