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Effect of O6-methylguanine on the stability of G-quadruplex DNA

Mekmaysy, C, Petraccome, L, Garbett, N, Ragazzon, PA, Gray, R, Trent, J and Chaires, J 2008, 'Effect of O6-methylguanine on the stability of G-quadruplex DNA' , Journal of the American Chemical Society, 130 (21) , pp. 6710-6711.

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Abstract

The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism, thermal denaturation, analytical ultracentrifugation, and molecular dynamics simulations. The results show that, while quadruplex structures can form containing the modified base, they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure

Item Type: Article
Themes: Health and Wellbeing
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Journal of the American Chemical Society
Publisher: American Chemical Society
Refereed: Yes
ISSN: 0002-7863
Related URLs:
Funders: National Cancel Institute (NCI)
Depositing User: PA Ragazzon
Date Deposited: 16 Jan 2015 11:51
Last Modified: 24 Mar 2015 15:27
URI: http://usir.salford.ac.uk/id/eprint/33306

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