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Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold

Alcaro, S, Artese, A, Iley, J, Maccari, R, Missailidis, S, Ortuso, F, Octana, R, Ragazzon, PA and Vigorita, M 2007, 'Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold' , Bioorganic & Medicinal Chemistry Letters, 1 (17) , pp. 2509-2514.

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Abstract

A series of fluorenone-carboxamide compounds was analyzed with regard to DNA binding properties by UV spectroscopy and competition dialysis methods. The morpholino derivative 10 provided interesting results in terms of affinity and specificity toward the DNA G-tetraplex structures. Interactions against this target were evaluated by a comparative molecular modeling study in agreement with the experimental data, proposing a model for the rational design of new agents with potent and selective DNA tetraplex binding properties

Item Type: Article
Themes: Health and Wellbeing
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Bioorganic & Medicinal Chemistry Letters
Publisher: Elsevier
Refereed: Yes
ISSN: 0960-894X
Related URLs:
Funders: MURST, Open University
Depositing User: PA Ragazzon
Date Deposited: 26 Jan 2015 14:39
Last Modified: 26 Jan 2015 14:39
URI: http://usir.salford.ac.uk/id/eprint/33313

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