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Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection

Gao, JM, Yi, SQ, Wu, MS, Geng, GQ, Shen, JL, Lu, FL, Hide, G, Lai, DH and Lun, ZR 2015, 'Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection' , Experimental Parasitology, 149 , pp. 47-53.

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Abstract

Mouse models differ considerably fromhumans with regard to clinical symptoms of toxoplasmosis caused by Toxoplasma gondii and, by comparison, the rat model is more representative of this disease in humans. In the present study, we found that different strains of adult and newborn rats (Lewis, Wistar, Sprague Dawley, Brown Norway and Fischer 344) exhibited remarkable variation in the number of brain cysts following inoculation with the T. gondii Prugniaud strain. In adult rats, large numbers of cysts (1231 ± 165.6) were observed in Fischer 344, but none in the other four. This situation was different in newborn rats aged from 5 to 20 days old. All Fischer 344 and Brown Norway newborns were cyst-positive while cystpositive infection in Sprague Dawley neonates ranged from 54.5% to 60% depending on their age at infection. In Wistar and Lewis rat neonates, however, cyst-positivity rates of 0–42.9% and 0–25% were found respectively. To investigate whether rat strain differences in infectivity could be related to inherent strain and genetic differences in the host immune response, we correlated our data with previously reported strain differences in iNOS/Arginase ratio in adult rats and found them to be linked. These results show that interactions between host genetic background and age of rat influence T. gondii infection.

Item Type: Article
Themes: Health and Wellbeing
Subjects outside of the University Themes
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Schools > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
Journal or Publication Title: Experimental Parasitology
Publisher: Elsevier
Refereed: Yes
ISSN: 0014-4894
Related URLs:
Funders: National Basic Research Program of China
Depositing User: Professor Geoff Hide
Date Deposited: 03 Feb 2015 11:35
Last Modified: 01 Mar 2016 01:38
URI: http://usir.salford.ac.uk/id/eprint/33380

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