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Amphibian symbiotic bacteria do not show universal ability to inhibit growth of the global pandemic lineage of Batrachochytrium dendrobatidis

Antwis, RE, Preziosi, RF, Harrison, X and Garner, TWJ 2015, 'Amphibian symbiotic bacteria do not show universal ability to inhibit growth of the global pandemic lineage of Batrachochytrium dendrobatidis' , Applied and Environmental Microbiology, 81 , pp. 3706-3711.

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Abstract

Microbiomes associated with multicellular organisms influence the disease susceptibility of hosts. The potential exists for such bacteria to protect wildlife from infectious diseases, particularly in the case of the globally distributed and highly virulent fungal pathogen Batrachochytrium dendrobatidis of the global panzootic lineage (B. dendrobatidis GPL), responsible for mass extinctions and population declines of amphibians. B. dendrobatidis GPL exhibits wide genotypic and virulence variation, and the ability of candidate probiotics to restrict growth across B. dendrobatidis isolates has not previously been considered. Here we show that only a small proportion of candidate probiotics exhibited broad-spectrum inhibition across B. dendrobatidis GPL isolates. Moreover, some bacterial genera showed significantly greater inhibition than others, but overall, genus and species were not particularly reliable predictors of inhibitory capabilities. These findings indicate that bacterial consortia are likely to offer a more stable and effective approach to probiotics, particularly if related bacteria are selected from genera with greater antimicrobial capabilities. Together these results highlight a complex interaction between pathogens and host-associated symbiotic bacteria that will require consideration in the development of bacterial probiotics for wildlife conservation. Future efforts to construct protective microbiomes should incorporate bacteria that exhibit broad-spectrum inhibition of B. dendrobatidis GPL isolates.

Item Type: Article
Themes: Subjects outside of the University Themes
Schools: Schools > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
Journal or Publication Title: Applied and Environmental Microbiology
Publisher: American Society for Microbiology
Refereed: Yes
ISSN: 0099-2240
Related URLs:
Funders: Biotechnology and Biosciences Sciences Research Council (BBSRC)
Depositing User: Dr Rachael Antwis
Date Deposited: 28 Sep 2015 17:37
Last Modified: 28 Sep 2015 17:37
URI: http://usir.salford.ac.uk/id/eprint/36703

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