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Targeting hypoxic response for cancer therapy

Paolicchi, E, Gemignani, F, Krstic-Demonacos, M, Dedhar, S, Mutti, L and Landi, S 2016, 'Targeting hypoxic response for cancer therapy' , Oncotarget, 7 (12) .

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Hypoxic tumor microenvironment (HTM) is considered to promote metabolic changes, oncogene activation, and epithelial mesenchymal transition, and resistance to chemo- and radio-therapy, all of which are hallmarks of aggressive tumor behavior. Cancer cells within the HTM acquire phenotypic properties that allow them to overcome the lack of energy and nutrients supply within this niche. These phenotypic properties include activation of genes regulating glycolysis, glucose transport, acidosis regulators, angiogenesis, all of which are orchestrated through the activation of the transcription factor, HIF1A, which is an independent marker of poor prognosis. Moreover, during the adaptation to a HTM cancer cells undergo deep changes in mitochondrial functions such as “Warburg effect” and the “reverse Warburg effect”. This review aims to provide an overview of the characteristics of the HTM, with particular focus on novel therapeutic strategies currently in clinical trials, targeting the adaptive response to hypoxia of cancer cells.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Oncotarget
Publisher: Impact Journals
ISSN: 1949-2553
Related URLs:
Funders: Non funded research
Depositing User: WM Taylor
Date Deposited: 01 Feb 2016 09:54
Last Modified: 12 Apr 2016 08:48

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