Mechanisms of adiponectin-associated perivascular function in vascular disease

Withers, SB, Bussey, CE, Saxton, SN, Melrose, HM, Watkins, AE and Heagerty, AM 2014, 'Mechanisms of adiponectin-associated perivascular function in vascular disease' , Arteriosclerosis, thrombosis, and vascular biology, 34 (8) , pp. 1637-42.

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Abstract

The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enough to explain disease states, such as hypertension and metabolic changes associated with obesity and type II diabetes mellitus. This ATVB in Focus intends to examine our current knowledge in this field, and suggests mechanisms that may be responsible for normal perivascular function and how they become disordered in obesity. There is the tantalizing prospect of developing new therapeutic approaches to keep obese individuals healthy and redesignating type II diabetes mellitus as a vascular disease.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Arteriosclerosis, thrombosis, and vascular biology
Publisher: American Heart Association
ISSN: 1524-4636
Related URLs:
Funders: BHF
Depositing User: Sarah Withers
Date Deposited: 15 May 2017 08:42
Last Modified: 10 Aug 2017 02:18
URI: http://usir.salford.ac.uk/id/eprint/38641

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