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Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer

Almelah, EBM, Smith, D, MCGOWN, A, Aziz, A, Potgieter, H and Ragazzon, PA 2016, 'Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer' , Anticancer Research . (In Press)

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Abstract

Abstract. Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We have developed a novel molecule, 2', 4'-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteoblasts cancer cell lines. Thionylation of 2', 4'- dihydroxydibenzoylmethane led to selective targeting of bone cancer cells, stopping their growth and leading to their death without affecting non-cancerous cells within the bone marrow or other non-malignant cells.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Anticancer Research
Publisher: International Institute of Anticancer Research (IIAR)
ISSN: 0250-7005
Funders: University of Salford teaching grant
Depositing User: PA Ragazzon
Date Deposited: 10 May 2016 15:01
Last Modified: 11 May 2016 07:52
URI: http://usir.salford.ac.uk/id/eprint/38925

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