Cancer stem cell metabolism
Peiris-Pagès, M, Martinez-Outschoorn, U, Pestell, R, Sotgia, Federica and Lisanti, M 2016, 'Cancer stem cell metabolism' , Breast Cancer Research, 18 (55) .
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Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.
|Schools:||Schools > School of Environment and Life Sciences > Biomedical Research Centre|
|Journal or Publication Title:||Breast Cancer Research|
|Publisher:||BioMed Central Ltd|
|Funders:||Funder not known|
|Depositing User:||Federica Sotgia|
|Date Deposited:||29 Jun 2016 07:43|
|Last Modified:||05 Jul 2016 09:38|
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