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Cancer metabolism : a therapeutic perspective

Martinez-Outschoorn, U, Peiris-Pagés, M, Pestell, R, Sotgia, Federica and Lisanti, M 2016, 'Cancer metabolism : a therapeutic perspective' , Nature Reviews Clinical Oncology .

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Abstract

Awareness that the metabolic phenotype of cells within tumours is heterogeneous — and distinct from that of their normal counterparts — is growing. In general, tumour cells metabolize glucose, lactate, pyruvate, hydroxybutyrate, acetate, glutamine, and fatty acids at much higher rates than their nontumour equivalents; however, the metabolic ecology of tumours is complex because they contain multiple metabolic compartments, which are linked by the transfer of these catabolites. This metabolic variability and flexibility enables tumour cells to generate ATP as an energy source, while maintaining the reduction–oxidation (redox) balance and committing resources to biosynthesis — processes that are essential for cell survival, growth, and proliferation. Importantly, experimental evidence indicates that metabolic coupling between cell populations with different, complementary metabolic profiles can induce cancer progression. Thus, targeting the metabolic differences between tumour and normal cells holds promise as a novel anticancer strategy. In this Review, we discuss how cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression; in particular, we highlight potential metabolic vulnerabilities that might be targeted therapeutically.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Nature Reviews Clinical Oncology
Publisher: Macmillan Publishers Limited
ISSN: 1759-4774
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Funders: Non funded research
Depositing User: F Sotgia
Date Deposited: 07 Jul 2016 09:45
Last Modified: 19 Sep 2016 08:48
URI: http://usir.salford.ac.uk/id/eprint/39270

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