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Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose

Peiris-Pagès, M, Sotgia, Federica and Lisanti, M 2015, 'Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose' , Oncoscience, 2 (8) , pp. 696-699.

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Abstract

There is a small proportion of cells within a tumour with self-renewing properties, which is resistant to conventional therapy, and is responsible for tumour initiation, maintenance and metastasis. These cells are known as cancer stem cells (CSCs) or tumour-initiating cells (TICs) [1]. Recent publications identify several antibiotics, such as salinomycin or doxycycline, as selective CSCs inhibitors [2-4]. However, the mechanisms of action of these antibiotics on CSCs are not fully understood.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Oncoscience
Publisher: Impact Journals, LLC
ISSN: 2331-4737
Related URLs:
Funders: Non funded research
Depositing User: Federica Sotgia
Date Deposited: 29 Jun 2016 08:01
Last Modified: 29 Jun 2016 08:01
URI: http://usir.salford.ac.uk/id/eprint/39275

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