Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose
Peiris-Pagès, M, Sotgia, Federica and Lisanti, M 2015, 'Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose' , Oncoscience, 2 (8) , pp. 696-699.
- Published Version
Available under License Creative Commons Attribution.
Download (722kB) | Preview
There is a small proportion of cells within a tumour with self-renewing properties, which is resistant to conventional therapy, and is responsible for tumour initiation, maintenance and metastasis. These cells are known as cancer stem cells (CSCs) or tumour-initiating cells (TICs) . Recent publications identify several antibiotics, such as salinomycin or doxycycline, as selective CSCs inhibitors [2-4]. However, the mechanisms of action of these antibiotics on CSCs are not fully understood.
|Schools:||Schools > School of Environment and Life Sciences > Biomedical Research Centre|
|Journal or Publication Title:||Oncoscience|
|Publisher:||Impact Journals, LLC|
|Funders:||Non funded research|
|Depositing User:||Federica Sotgia|
|Date Deposited:||29 Jun 2016 08:01|
|Last Modified:||29 Jun 2016 08:01|
Actions (login required)
|Edit record (repository staff only)|