Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques

Latimer, J, Munday, JL, Buzza, KM, Sreenivasan, PK and McBain, AJ 2015, 'Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques' , American Journal of Dentistry, 28 Spe , 9A-13A.

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Abstract

PURPOSE To assess the antimicrobial effects of a fluoride-free and alcohol-free mouthrinse containing 0.075% CPC (test rinse, TR) compared with an otherwise-identical CPC-free control rinse (CR). METHODS Activity against laboratory cultures of Fusobacterium nucleatum, a bacterium associated with gingival disease, was determined using viable counting following 30-second exposures to TR and CR. Effects against intact saliva-derived plaque biofilms were quantified using confocal microscopy coupled with three-dimensional image analyses (viability profiling). RESULTS Short exposures to TR caused significant inactivation of F. nucleatum, as determined by viable counting (c. 3 log reduction compared to the control rinse, P < 0.05). Confocal microscopy revealed extensive inactivation of complex oral biofilms following treatment with TR; biofilms were significantly less viable than those exposed to CR and three-dimensional images revealed extensive zones of dead bacteria even within plaque depths. In conclusion, this investigation demonstrates that the CPC-containing mouthrinse has significant antibacterial efficacy against oral bacteria associated with gingival disease and significantly inactivated plaque biofilm in comparison to a relevant control.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: American Journal of Dentistry
Publisher: Mosher and Linder Inc
ISSN: 0894-8275
Funders: Colgate Palmolive
Depositing User: J Latimer
Date Deposited: 24 Oct 2016 10:27
Last Modified: 24 Oct 2016 10:30
URI: http://usir.salford.ac.uk/id/eprint/39966

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