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The role of 18F-sodium fluoride PET/CT bone scans in the diagnosis of metastatic bone disease from breast and prostate cancer

Kulshrestha, R, England, A, Nightingale, J, Vinjamuri, R and Hogg, P 'The role of 18F-sodium fluoride PET/CT bone scans in the diagnosis of metastatic bone disease from breast and prostate cancer' , Journal of Nuclear Medicine Technology . (In Press)

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Abstract

This article shall describe the role of 18F-Sodium Fluoride (18F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer. 18F-NaF PET was initially utilised as a bone scanning agent in the 1960s and early 1970s, however its usage was restricted by the then available gamma cameras. The advent of hybrid PET/CT cameras in the late 1990s has shown a resurgence of interest in its usage and role. After a brief introduction, this paper will describe the radiopharmaceutical properties, dosimetry, pharmacokinetics, and mechanism of uptake of 18F-NaF. The performance of 18F-NaF PET/CT is then compared with conventional bone scintigraphy utilizing current evidence from the literature. Strengths and weaknesses of 18F-NaF PET/CT imaging shall be highlighted. Clinical examples of improved accuracy of diagnosis and impact on patient management shall be illustrated. Limitations of 18F-NaF PET/CT imaging will be outlined.

Item Type: Article
Schools: Schools > School of Health Sciences > Centre for Health Sciences Research
Journal or Publication Title: Journal of Nuclear Medicine Technology
Publisher: Society of Nuclear Medicine (America)
ISSN: 0091-4916
Funders: Non funded research
Depositing User: P Hogg
Date Deposited: 01 Sep 2016 07:58
Last Modified: 05 Sep 2016 07:46
URI: http://usir.salford.ac.uk/id/eprint/39984

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