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The formation of colloidal crystals of lipid A diphosphate: evidence for the formation of nanocrystals at low ionic strength

Faunce, CA, Reichelt, H, Paradies, HH, Quitschau, P, Rusch, V and Zimmermann, K 2003, 'The formation of colloidal crystals of lipid A diphosphate: evidence for the formation of nanocrystals at low ionic strength' , The Journal of Physical Chemistry B, 107 (37) , pp. 9943-9946.

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Abstract

Dilute electrostatically stabilized aqueous solutions of hexa-acylated (C14) lipid A diphosphate from Escherichia coli form stable and regularly shaped colloidal crystals in a size range of approximately 50-1000 nm in width and 50-100 nm in thickness. The formation of these nanocrystals occurs over a range of volume fractions between 3.5 × 10-3 and 1.2 × 10-2 and at a low ionic strength, ~10-5. The shape of these crystals appears to be cubic or rhombohedral, and when exposed to the electron beam, these fragile nanocrystals are easily damaged. Electron diffraction patterns obtained from single particles reveal that they are orientated (001) crystals that conform to a trigonal or hexagonal unit cell (a = 3.65 ± 0.07 nm and c = 1.97 ± 0.04 nm), revealing crystal-like pore walls that exhibit structural periodicity with a spacing of 0.65 nm and are at least four times the size of the unit cell adopted by lipid A diphosphate.

Item Type: Article
Themes: Subjects / Themes > Q Science > QD Chemistry
Subjects / Themes > Q Science > QC Physics
Subjects outside of the University Themes
Schools: Colleges and Schools > College of Science & Technology
Colleges and Schools > College of Science & Technology > School of Computing, Science and Engineering
Journal or Publication Title: The Journal of Physical Chemistry B
Publisher: American Chemical Society
Refereed: Yes
ISSN: 15206106
Depositing User: H Kenna
Date Deposited: 05 Sep 2007 14:26
Last Modified: 20 Aug 2013 16:47
URI: http://usir.salford.ac.uk/id/eprint/400

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