Lamellar body exocytosis by cell stretch or purinergic stimulation : possible physiological roles, messengers and mechanisms

Dietl, P, Liss, B, Felder, E, Miklavc, P and Wirtz, H 2010, 'Lamellar body exocytosis by cell stretch or purinergic stimulation : possible physiological roles, messengers and mechanisms' , Cellular Physiology and Biochemistry, 25 (001) , 001-012.

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Abstract

A major function of the pulmonary alveolar type II cell is the secretion of surfactant, a lipoprotein-like substance, via exocytosis of secretory vesicles termed lamellar bodies (LBs). The process of surfactant secretion is remarkable in several aspects, considering stimulus-delayed fusion activity, poor solubility of vesicle contents, long hemifusion lifetimes, slow fusion pore expansion and active, actin-driven content release. Cell stretch as well as P2Y2 receptor stimulation by extracellular ATP are considered the most potent stimuli for LB exocytosis. For both stimuli, elevation of the cytoplasmic Ca2+ concentration [Ca2+]c is a key step. This review summarizes possible physiological roles and pathways of stretch- or ATP-induced surfactant secretion and discusses molecular mechanisms controlling the pre-, hemi- and postfusion phase, in comparison with neuroendocrine release mechanisms.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences
Journal or Publication Title: Cellular Physiology and Biochemistry
Publisher: Karger Publishers Open Access
ISSN: 1015-8987
Related URLs:
Funders: Deutsche Forschungsgemeinschaft, Alfried Krupp Prize of the Krupp Foundation
Depositing User: P Miklavc
Date Deposited: 02 Nov 2016 10:18
Last Modified: 08 Aug 2017 16:56
URI: http://usir.salford.ac.uk/id/eprint/40264

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