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Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides

Krpetic, Z, Singh, I, Su, W, Guerrini, L, Faulds, K, Burley, GA and Graham, D 2012, 'Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides' , Journal of the American Chemical Society, 134 (20) , pp. 8356-8359.

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Traditional methods for the construction of nanoparticle arrays and lattices exploit Watson–Crick base pairing of single-stranded DNA sequences as a proxy for self-assembly. Although this approach has been utilized in a variety of applications in nanoassembly, diagnostics, and biomedicine, the diversity of this recognition lexicon could be considerably increased by developing strategies that recognize the base-pairing landscape of double-stranded DNA (dsDNA) sequences. Herein we describe the first report of programmed gold nanoparticle (GNP) aggregation directed by the recognition of dsDNA sequences using pyrrole–imidazole polyamide–GNP (PA–GNP) conjugates. We demonstrate the reversibility and selectivity of this strategy for forming GNP aggregates in the presence of fully matched dsDNA sequences relative to dsDNA sequences containing one- and two-base-pair mismatches.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Journal of the American Chemical Society
Publisher: American Chemical Society
ISSN: 0002-7863
Related URLs:
Funders: Engineering and Physical Sciences Research Council (EPSRC), Royal Society
Depositing User: Dr Zeljka Krpetic
Date Deposited: 06 Oct 2016 15:14
Last Modified: 06 Oct 2016 15:14

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