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Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity

Cioran, AM, Musteti, AD, Teixidor, F, Krpetic, Z, Prior, IA, He, Q, Kiely, CJ, Brust, M and Viñas, C 2012, 'Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity' , Journal of the American Chemical Society, 134 (1) , pp. 212-221.

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Abstract

A simple single-phase method for the preparation of ca. 2 nm gold nanoparticles capped with mercaptocarborane ligands is introduced. The resultant monolayer protected clusters (MPCs) exhibit redox-dependent solubility and readily phase transfer between water and nonpolar solvents depending on the electronic and ionic charge stored in the metal core and in the ligand shell, respectively. The particles and their properties have been characterized by high angle annular dark field imaging in a scanning transmission electron microscope, elemental analysis, centrifugal particle sizing, UV–vis and FTIR spectroscopy, and thermogravimetric analysis and by 1H, 11B, and 7Li NMR spectroscopy. Cellular uptake of the MPCs by HeLa cells has been studied by TEM, and the subsequent generation of reactive oxygen species inside the cells has been evaluated by confocal fluorescence microscopy. These MPCs qualitatively showed significant toxicity and the ability to penetrate into most cell compartments with a strong tendency of finally residing inside membranes. Applications in catalysis, electrocatalysis, and biomedicine are envisaged.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Journal of the American Chemical Society
Publisher: American Chemical Society
ISSN: 0002-7863
Related URLs:
Funders: MEC, Generalitat de Catalunya
Depositing User: Dr Zeljka Krpetic
Date Deposited: 11 Oct 2016 14:30
Last Modified: 11 Oct 2016 14:30
URI: http://usir.salford.ac.uk/id/eprint/40298

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