Energy dependence of gold nanoparticle radiosensitization in plasmid DNA

McMahon, SJ., Hyland, WB, Brun, E, Butterworth, KT, Coulter, JA, Douki, T, Hirst, DG, Jain, S, Kavanagh, AP, Krpetic, Z, Mendenhall, MH, Muir, MF, Prise, KM, Requardt, H, Sanche, L, Schettino, G, Currell, FJ and Sicard-Roselli, C 2011, 'Energy dependence of gold nanoparticle radiosensitization in plasmid DNA' , The Journal of Physical Chemistry C, 115 (41) , pp. 20160-20167.

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Gold nanopa rticles (GNPs) are of considerableinterest for use as a radiosensitizer, because of their biocompat-ibility and their ability to increase dose deposited because oftheir high mass energy absorption coefficient. Their sensitizingproperties have been verified experimentally, but a discrepancybetween the exper imental results and theoretical predictionssuggests that the sensitizing effect does not depend solely ongold’s superior absorption of energetic photons. Thi s workpresents the results of three sets of experiments that indepen-dently mapped out the energy dependence of the radiosensitiz-ing effects of GNPs on plasmid DNA suspended in water. Incident photon energy was varied from 11.8 to 80 keV through the use ofmonochromatic synchrotron and broadband X-rays. These results depart significantly from the theoretical predictions in two ways:First, the sensitization is signi ficantly larger than would be predicted; second, it does not vary with energy as would be predicted fromenergy absorption coefficients. These results clearly demonstra te that the effects of GNP-enhanced therapies cannot be predicted byconsidering additional dose alone and that a greater understanding of the processes involved is necessary for the development offuture therapeutics

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: The Journal of Physical Chemistry C
Publisher: American Chemical Society
ISSN: 1932-7447
Related URLs:
Funders: Cancer Research UK
Depositing User: Dr Zeljka Krpetic
Date Deposited: 11 Oct 2016 14:33
Last Modified: 11 Oct 2016 14:33

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