Energy dependence of gold nanoparticle radiosensitization in plasmid DNA

McMahon, SJ., Hyland, WB, Brun, E, Butterworth, KT, Coulter, JA, Douki, T, Hirst, DG, Jain, S, Kavanagh, AP, Krpetic, Z ORCID: 0000-0003-1129-6831, Mendenhall, MH, Muir, MF, Prise, KM, Requardt, H, Sanche, L, Schettino, G, Currell, FJ and Sicard-Roselli, C 2011, 'Energy dependence of gold nanoparticle radiosensitization in plasmid DNA' , The Journal of Physical Chemistry C, 115 (41) , pp. 20160-20167.

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Abstract

Gold nanopa rticles (GNPs) are of considerableinterest for use as a radiosensitizer, because of their biocompat-ibility and their ability to increase dose deposited because oftheir high mass energy absorption coefficient. Their sensitizingproperties have been verified experimentally, but a discrepancybetween the exper imental results and theoretical predictionssuggests that the sensitizing effect does not depend solely ongold’s superior absorption of energetic photons. Thi s workpresents the results of three sets of experiments that indepen-dently mapped out the energy dependence of the radiosensitiz-ing effects of GNPs on plasmid DNA suspended in water. Incident photon energy was varied from 11.8 to 80 keV through the use ofmonochromatic synchrotron and broadband X-rays. These results depart significantly from the theoretical predictions in two ways:First, the sensitization is signi ficantly larger than would be predicted; second, it does not vary with energy as would be predicted fromenergy absorption coefficients. These results clearly demonstra te that the effects of GNP-enhanced therapies cannot be predicted byconsidering additional dose alone and that a greater understanding of the processes involved is necessary for the development offuture therapeutics

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: The Journal of Physical Chemistry C
Publisher: American Chemical Society
ISSN: 1932-7447
Related URLs:
Funders: Cancer Research UK
Depositing User: Dr Zeljka Krpetic
Date Deposited: 11 Oct 2016 14:33
Last Modified: 11 Oct 2016 14:33
URI: http://usir.salford.ac.uk/id/eprint/40300

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