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Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles

Krpetic, Z, Nativo, P, Sée, V, Prior, IA, Brust, M and Volk, M 2010, 'Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles' , Nano Letters, 10 (11) , pp. 4549-4554.

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Abstract

We show that low-intensity laser irradiation of cancer cells containing endosomal gold nanoparticles leads to endosome rupture and escape of the nanoparticles into the cytosol without affecting the cells’ viability. The low light intensity of our experiments allows us to rule out photothermal effects as the underlying mechanism, and we present results that suggest photoinduced radicals as the photogenerated active species. This nonthermal mechanism may also be important in the context of cell death at higher laser intensities, which had been reported previously.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Nano Letters
Publisher: American Chemical Society
ISSN: 1530-6984
Related URLs:
Funders: European Commission, Biotechnology and Biosciences Sciences Research Council (BBSRC)
Depositing User: Dr Zeljka Krpetic
Date Deposited: 11 Oct 2016 14:36
Last Modified: 11 Oct 2016 14:36
URI: http://usir.salford.ac.uk/id/eprint/40304

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