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Phagocytosis of biocompatible gold nanoparticles

Krpeticc, Z, Porta, F, Caneva, E, Dal Santo, V and Scarì, G 2010, 'Phagocytosis of biocompatible gold nanoparticles' , Langmuir, 26 (18) , pp. 14799-14805.

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Abstract

We report the evidence for the cellular uptake of gold nanoparticles via the phagocytosis mechanism in murine macrophage cells strongly supported by TEM and optical microscopy. Nanoparticles were prepared using several biocompatible molecules of choice (5-aminovaleric acid, l-DOPA, melatonin, and serotonin hydrochloride) as stabilizers for gold colloids. Their surface chemistry was fully characterized by UV−vis, ATR-FTIR, 1H NMR, and HR-MAS 1H NMR spectroscopies, and size distribution was determined by CPS disc centrifuge and TEM. Differences in coatings were evaluated against cellular uptake, and a preferential movement of macrophages toward 5-aminovaleric acid-modified gold nanoparticles was shown, leading to the fast accumulation of nanoparticles in the cytosol.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Journal or Publication Title: Langmuir
Publisher: American Chemical Society
ISSN: 0743-7463
Related URLs:
Funders: Fondazione CARIPLO
Depositing User: Dr Zeljka Krpetic
Date Deposited: 11 Oct 2016 14:37
Last Modified: 11 Oct 2016 14:37
URI: http://usir.salford.ac.uk/id/eprint/40305

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