Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering

Marco A, C., P, Krpetic, Z, Tiziano, S, Qi, C, Marco, M, João M., de A, Claudia, C, Luca, B, Valentina, C, Paolo, M and Kenneth A., D 2017, 'Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering' , Nanoscale, 8 .

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Abstract

The shape and size of nanoparticles are important parameters affecting the biodistribution, bioactivity, and toxicity. The high-throughput characterisation of nanoparticle shape in the dispersion is a fundamental prerequisite for realistic in vitro and in vivo evaluation, however, with routinely available bench-top optical characterisation techniques, it remains a challenging task. Herein, we demonstrate the efficacy of Single Particle Extinction and Scattering (SPES) technique for the in situ detection of the shape of nanoparticles in dispersion, applied to a small library of anisotropic gold particles, with potential developments of in-line detection. The use of SPES paves the way to the routine quantitative analysis of nanoparticles dispersed in biologically relevant fluids, which is of importance for the nanosafety assessment and any in vitro and in vivo administration of nanomaterials.

Item Type: Article
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Schools > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
Journal or Publication Title: Nanoscale
Publisher: The Royal Society of Chemistry
ISSN: 2040-3364
Related URLs:
Funders: European Commission
Depositing User: Dr Zeljka Krpetic
Date Deposited: 20 Jan 2017 15:00
Last Modified: 10 Aug 2017 02:15
URI: http://usir.salford.ac.uk/id/eprint/41247

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