A review on hyperthermia via nanoparticle-mediated therapy

Beg, OA, Sohail, A, Ahmed, Z, Arshad, S and Sherin, L 2017, 'A review on hyperthermia via nanoparticle-mediated therapy' , Bulletin du Cancer, 104 (5) , pp. 452-461.

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Abstract

Hyperthermia treatment, generated by magnetic nanoparticles (MNPs) is promising since it is tumour-focused, minimally invasive and uniform. The most unique feature of magnetic nanoparticles is their reaction to and manipulation by a magnetic force which is responsible for enabling their potential as heating mediators for cancer therapy. With magnetic nanoparticle hyperthermia, a tumour is preferentially loaded with systemically administered nanoparticles with high-absorption cross section for transduction of an extrinsic energy source to heat. To maximize the energy deposited in the tumour while limiting the exposure in healthy tissues, the heating is achieved by exposing the region of tissue containing magnetic nanoparticles to an alternating magnetic field. The magnetic nanoparticles dissipate heat from relaxation losses thereby heating localized tissue above normal physiological ranges. Besides thermal efficiency, the biocompatibility of magnetite nanoparticles assists in their deployment as efficient drug carriers for targeted therapeutic regimes. In the present article we provide a state-of-the-art review focused on progress in nanoparticle induced hyperthermia treatments which have several potential advantages over both global and local hyperthermia treatments achieved without nanoparticles. Green bio-nanotechnology has attracted substantial attention and has demonstrable abilities to improve cancer therapy. Furthermore we have listed the challenges associated with this treatment along with future opportunities in this field which it is envisaged will be of interest to biomedical engineers, bio-materials scientists, medical researchers and pharmacological research groups.

Item Type: Article
Schools: Schools > School of Computing, Science and Engineering
Journal or Publication Title: Bulletin du Cancer
Publisher: Elsevier
ISSN: 0007-4551
Related URLs:
Depositing User: OA Beg
Date Deposited: 07 Feb 2017 10:37
Last Modified: 09 Aug 2017 15:13
URI: http://usir.salford.ac.uk/id/eprint/41346

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