Different types of small RNAs in protozoa

Zheng, LL, Liao, JY, Wen, YZ, Hide, G, Qu, LH and Lun, ZR 2016, 'Different types of small RNAs in protozoa' , in: Non-coding RNAs and inter-kingdom communication , Springer International Publishing, pp. 177-196.

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Abstract

The origin and evolution of small RNA molecules is a long-standing mystery. The protozoa represent the earliest eukaryotes and encompass rich diverse genetic resources. However, there are many contradictions and disputes prevalent in studies on protozoan microRNAs. In this review, we summarize the research on the analysis of small RNA transcriptome data on two representative protozoans, Trypanosoma brucei and Giardia lamblia , as generated by high throughput sequencing. The results show that these protozoans do not have canonical miRNAs. Unexpectedly, there are many types of endogenous small interfering RNAs (endo-siRNAs). In addition, stress induced tRNA derived small RNAs (sitRNAs) were observed in different life cycle stages of these parasites. In total, there are six kinds of sitRNAs in G. lamblia . These small RNAs are then found to be involved in the differentiation processes of primitive eukaryotes . These results showed that systematic analysis of small RNAs in the protozoa revealed a more complex picture than previously thought

Item Type: Book Section
Editors: Leitao, AL and Enguita, FJ
Schools: Schools > School of Environment and Life Sciences > Biomedical Research Centre
Schools > School of Environment and Life Sciences > Ecosystems and Environment Research Centre
Publisher: Springer International Publishing
ISBN: 9783319394947
Related URLs:
Depositing User: Professor Geoff Hide
Date Deposited: 02 Mar 2017 11:05
Last Modified: 08 Aug 2017 19:41
URI: http://usir.salford.ac.uk/id/eprint/41528

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